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371708

Gβγ Modulator II, Gallein

Name: Gβγ Modulator II, Gallein
Brand: MM

A cell-permeable xanthene compound that binds to Gβγ with high affinity (K_d ~400 nM derived from a surface plasma resonance binding study using Gβ1γ2) and blocks Gβγ-dependent cellular activities.

Synonym(s):

Gβγ Modulator II, Gallein, 4,5-Dihydroxyfluorescein, dihydrate, 2-(3,4,5-Trihydroxy-6-oxoxanthen-9-yl)-benzoic acid, dihydrate

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₁₂O₇ · 2H₂O

CAS Number:

2103-64-2

Molecular Weight:

400.34

MDL number:

MFCD00041839

UNSPSC Code:

12171500

NACRES:

NA.77

Assay:

≥90% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, protect from light

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Properties

Quality Level

100

assay

≥90% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

burgundy

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

O1C3(c4c(c(c(cc4)O)O)Oc5c3ccc(c5O)O)c2c(cccc2)C1=O

InChI

1S/C20H12O7/c21-13-7-5-11-17(15(13)23)26-18-12(6-8-14(22)16(18)24)20(11)10-4-2-1-3-9(10)19(25)27-20/h1-8,21-24H

InChI key

PHLYOKFVXIVOJC-UHFFFAOYSA-N

Description

General description

A cell-permeable xanthene compound that binds to Gβγ with high affinity (K_d ~400 nM derived from a surface plasma resonance binding study using Gβ₁γ₂) and blocks Gβγ-dependent cellular activities. Reported to exhibit in vivo prophylactic efficacy against carrageenan-induced neutrophil recruitment and tissue swelling in a murine paw edema model via either intraperitoneal or oral administration.

Packaging

Packaged under inert gas

Other Notes

Lehmann, D.M., et al. 2008. Mol. Pharmacol.73, 410.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c