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371958

H-8, Dihydrochloride

A potent, cell-permeable, reversible, and ATP-competitive inhibitor of cyclic-nucleotide-dependent protein kinases.

Synonym(s):

H-8, Dihydrochloride, N-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamide, 2HCl, PKA Inhibitor I

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About This Item

Empirical Formula (Hill Notation):
C12H15N3O2S · 2HCl
CAS Number:
113276-94-1
Molecular Weight:
338.25
UNSPSC Code:
12352200
MDL number:
MFCD00036962
Assay:
>95% (TLC)
Form:
lyophilized
Quality level:
100
Storage condition:
OK to freeze
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Quality Level

100

assay

>95% (TLC)

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

solubility

water: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C12H15N3O2S.2ClH/c1-13-7-8-15-18(16,17)12-4-2-3-10-9-14-6-5-11(10)12;;/h2-6,9,13,15H,7-8H2,1H3;2*1H

InChI key

RJJLZYZEVNCZIW-UHFFFAOYSA-N

General description

A potent, cell-permeable, reversible, and ATP-competitive, and highly active inhibitor of cyclic-nucleotide-dependent protein kinases. Inhibits myosin light chain kinase (Ki = 68 µM), protein kinase A (Ki = 1.2 µM), protein kinase C (Ki = 15 µM), and protein kinase G (Ki = 480 nM).

Biochem/physiol Actions

Cell permeable: yes
Product competes with ATP.
Reversible: yes
Target Ki: 68 µM against MLCK

Preparation Note

Further dilute with aqueous buffer just prior to use.

Other Notes

Ido, M., et al. 1991. Br. J. Cancer 64, 1103.
Hagiwara, M., et al. 1987. Mol. Pharmacol. 31, 523.
Inagaki, M., et al. 1986. Mol. Pharmacol.29, 577.
Hidaka, H., et al. 1984. Biochemistry23, 5036.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Global Trade Item Number

SKUGTIN
371958-1MG04055977213508