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About This Item
Empirical Formula (Hill Notation):
C12H15N3O2S · 2HCl
CAS Number:
Molecular Weight:
338.25
MDL number:
UNSPSC Code:
12352200
Quality Level
Assay
>95% (TLC)
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
solubility
water: 10 mg/mL
shipped in
ambient
storage temp.
2-8°C
InChI
1S/C12H15N3O2S.2ClH/c1-13-7-8-15-18(16,17)12-4-2-3-10-9-14-6-5-11(10)12;;/h2-6,9,13,15H,7-8H2,1H3;2*1H
InChI key
RJJLZYZEVNCZIW-UHFFFAOYSA-N
General description
A potent, cell-permeable, reversible, and ATP-competitive, and highly active inhibitor of cyclic-nucleotide-dependent protein kinases. Inhibits myosin light chain kinase (Ki = 68 µM), protein kinase A (Ki = 1.2 µM), protein kinase C (Ki = 15 µM), and protein kinase G (Ki = 480 nM).
Biochem/physiol Actions
Cell permeable: yes
Product competes with ATP.
Reversible: yes
Target Ki: 68 µM against MLCK
Preparation Note
Further dilute with aqueous buffer just prior to use.
Other Notes
Ido, M., et al. 1991. Br. J. Cancer 64, 1103.
Hagiwara, M., et al. 1987. Mol. Pharmacol. 31, 523.
Inagaki, M., et al. 1986. Mol. Pharmacol.29, 577.
Hidaka, H., et al. 1984. Biochemistry23, 5036.
Hagiwara, M., et al. 1987. Mol. Pharmacol. 31, 523.
Inagaki, M., et al. 1986. Mol. Pharmacol.29, 577.
Hidaka, H., et al. 1984. Biochemistry23, 5036.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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