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382155

Histone Deacetylase Substrate, Fluorogenic

Name: Histone Deacetylase Substrate, Fluorogenic
Brand: MM

Synonym(s):

Histone Deacetylase Substrate, Fluorogenic, Boc-Lys(Ac)-AMC, MAL, N-(4-Methyl-7-coumarinyl)-N ^α-(t-butoxycarbonyl)-N ^ω-acetyllysinamide

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₃₁N₃O₆

CAS Number:

233691-67-3

Molecular Weight:

445.51

UNSPSC Code:

12352200

Assay:

≥98% (HPLC)

Form:

crystalline solid

Quality level:

100

Storage condition:

OK to freeze, protect from light

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Properties

assay

≥98% (HPLC)

Quality Level

100

form

crystalline solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

ethanol: 1 mg/mL, DMSO: 5 mg/mL

fluorescence

λ_ex 330 nm, λ_em 395 nm

shipped in

ambient

storage temp.

−20°C

InChI

1S/C23H31N3O6/c1-14-12-20(28)31-19-13-16(9-10-17(14)19)25-21(29)18(8-6-7-11-24-15(2)27)26-22(30)32-23(3,4)5/h9-10,12-13,18H,6-8,11H2,1-5H3,(H,24,27)(H,25,29)(H,26,30)/t18-/m0/s1

InChI key

SUTRDULVNIPNLW-SFHVURJKSA-N

Description

General description

A fluorogenic substrate for histone deacetylase (HD; excitation maximum: 330 nm; emission maximum: 395 nm).

Note: The histone deacetylase will cleave the Ac group and after the enzymatic reaction 2 peaks will be visible on HPLC. Before the reaction HPLC shows only one peak. The measure of second peak gives the degree of hydrolysis. It is important to use HPLC equipped with a fluorescence detector.

Other Notes

Hoffmann, K., et al. 1999. Nucleic Acids Res.27, 2057.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c