400089
HIF-1α/2α Inhibitor IV, FM19G11 - CAS 329932-55-0 - Calbiochem
Synonym(s):
2-(4-Methylphenyl)-2-oxoethyl-3-((2,4-dinitrobenzoyl)amino)benzoate, HIF Inhibitor IV, 2-Oxo-2-((p-tolyl)ethyl)-3-((2,4-dinitro)benzamido)-benzoate
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assay
≥95% (HPLC)
form
solid
color
pale amber
solubility
DMSO: 100 mg/mL
General description
A cell-permeable benzamido-benzoate compound that is shown to prevent hypoxia-induced increase in HIF-1α and HIF-2α protein levels in HeLa cultures, resulting in a blockage of HIF Responsive Element- (HRE) mediated transcription activity under hypoxia (1% O2) condition (IC50 = 80 nM in HeLa-based luciferase reporter assays). FM19G11 treatment is also reported to decrease HIF-2α-dependent Oct4 and Sox2 mRNA accumulation under hypoxia condition in a dose-dependent manner in both rat epSPC (ependymal stem/progenitor cell) and human hESC (embryonic stem cell) cultures, resulting in a 50% drop of cellular Oct4 and Sox2 protein level after 48 h with 500 nM FM19G11.
The HIF-1α/2α Inhibitor IV, FM19G11 controls the biological activity of HIF-1α/2α. This small molecule/inhibitor is primarily used for Cell Structure applications.
Preparation Note
Use only fresh DMSO for reconstitution. Following reconstitution, aliquot and freeze (-20°C). Stock solutions stable for up to 3 months at -20°C.
Storage Class
10-13 - German Storage Class 10 to 13
Regulatory Information
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Victoria Moreno-Manzano et al.
The Journal of biological chemistry, 285(2), 1333-1342 (2009-11-10)
The biology of the alpha subunits of hypoxia-inducible factors (HIFalpha) has expanded from their role in angiogenesis to their current position in the self-renewal and differentiation of stem cells. The results reported in this article show the discovery of FM19G11