401006
Hypoestoxide, Hypoestes rosea
A naturally occurring, cell-permeable diterpene with anti-inflammatory properties.
Synonym(s):
Hypoestoxide, Hypoestes rosea
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About This Item
Empirical Formula (Hill Notation):
C22H32O5
Molecular Weight:
376.49
UNSPSC Code:
12352200
Assay:
≥97% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
Quality Level
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 3 mg/mL (slight warming may be required), ethanol: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A naturally occurring, cell-permeable diterpene with anti-inflammatory properties. Acts as a selective and direct inhibitor of IκB kinase (IC50 = 24 µM) in TNF-α stimulated HeLa cells thereby prevents NF-κB activation. Also inhibits the production of nitric oxide in IL-1β or IL-17 stimulated normal human chondrocytes. Does not inhibit the activities of JNK and p38MAPK. Reported to be effective against murine blood and liver stages of malarial parasites. Inhibits VEGF-induced cell proliferation in vitro (IC50 = 28.6 µM) and bFGF-induced angiogenesis in the chick chorioallantoic membrane (IC50 = 10 µM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
IKB Kinase
IKB Kinase
Product does not compete with ATP.
Reversible: no
Target IC50: 24 µM against IκB kinase
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions in DMSO are stable for up to 2 weeks at -20°C. Stock solutions in ethanol are stable for up to 2 months at -20°C.
Other Notes
Pulai, J.I., et al. 2005. J. Immunol.174, 5781.
Ojo-Amaize, E. A., et al. 2002. Cancer Res.62, 4007.
Ojo-Amaize, E.A., et al. 2001. Cell Immunol.209, 149.
Ojo-Amaize, E. A., et al. 2002. Cancer Res.62, 4007.
Ojo-Amaize, E.A., et al. 2001. Cell Immunol.209, 149.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 401006-1MG | 04055977189384 |