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401251

IM-412

Name: IM-412
Brand: MM

IM-412 primarily used in Inhibition.

Synonym(s):

IM-412, 3-(2-chlorobenzyl)-1,7-dimethyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione, TGF beta Inhibitor, IM-412

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₄ClN₅O₂

Molecular Weight:

343.77

NACRES:

NA.32

UNSPSC Code:

12352200

Assay:

≥90% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze

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Properties

Quality Level

100

assay

≥90% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

off-white

solubility

DMSO: 3 mg/mL

shipped in

ambient

storage temp.

2-8°C

Description

General description

A cell permeable imidazoxanthine shown to decrease TGF-β stimulated reporter activity in a dose-dependent manner in HEK293 reporter cells, with an IC₅₀ of 4.1 µM without cell cytotoxicity. Inhibits TGF-β receptor I (TβRI) and TGF-β receptor II (TβRII) expression and its downstream Smad2 and Smad3 phosphorylation as well as JNK and ERK activity. In addition, it elicits TGF-β-induced fibroblast differentiation with attenuated expression of several fibrotic markers such as α-SMA and fibronectin, and suppresses collagen accumulation in CCD-18Lu human normal lung fibroblasts.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Park, S., et al. 2010. Biochem. Biophy. Res. Comm.399, 268.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c