Assay
≥98% (HPLC)
form
solid
color
yellow
solubility
DMSO: 50 mg/mL
General description
A cell-permeable β-carboline compound that displays anti-inflammatory properties. Acts as a potent, ATP-competitive, and reversible inhibitor of IKK (IC50 = 88 nM) with selectivity over 14 other commonly studied kinases (IC50 >100 μM), including NF-κB inducing kinase. Blocks cellular IκBα phosphorylation and NF-κB activation (EC50 = 5 μM in TNF-α-treated HeLa cells) in vitro and reduces TNF-α release in plasma of LPS-challenged mice in vivo (50 mg/ml, p.o.).
The IKK Inhibitor X controls the biological activity of IKK. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
Biochem/physiol Actions
Target IC50:88 nM against IKK
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Storage Class Code
10-13 - German Storage Class 10 to 13
Certificates of Analysis (COA)
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