m-Iodobenzylguanidine, Hemisulfate - CAS 80663-95-2 - Calbiochem

Name: <i>m</i>-Iodobenzylguanidine, Hemisulfate - CAS 80663-95-2 - Calbiochem
Brand: MM

Synonym(s):

3-Iodobenzylguanidine, Hemisulfate, MIBG

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Properties

assay

≥99% (HPLC)

form

solid

color

colorless to white

solubility

H₂O: 20 mg/mL

Description

General description

A cell-permeable norepinephrine analog that displays antiproliferative and proapoptotic properties. Reported to competitively inhibit arginine-dependent mono-ADP-ribosylation, impair mitochondrial respiration, stimulate glycolysis, and prevent terminal differentiation of skeletal myoblasts reversibly. Readily taken up by tissues rich in sympathetic neurons and neuroendocrine neoplasm via norepinephrine transporters (NET). Inhibits the phosphorylation of the Rho effector, PRK1/2 with no effect on the stimulation of MAP and PI-3 kinases.

Biochem/physiol Actions

Arginine-dependent mono-ADP-ribosylation

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Storage Class

10-13 - German Storage Class 10 to 13

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