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407950

Ionomycin free acid

from Streptomyces conglobatus, ≥90% (HPLC), waxy solid, Ca2+ mobile ion carrier, Calbiochem®

Synonym(s):

Ionomycin, Free Acid, Streptomyces conglobatus

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About This Item

Empirical Formula (Hill Notation):
C41H72O9
CAS Number:
56092-81-0
Molecular Weight:
709.00
UNSPSC Code:
12352106
NACRES:
NA.77
MDL number:
MFCD06798385
Assay:
≥90% (HPLC)
Form:
waxy solid
Storage condition:
OK to freeze, protect from light
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Product Name

Ionomycin, Free Acid, Streptomyces conglobatus, Ionomycin, Free Acid, Streptomyces conglobatus, CAS 56092-81-0, is a highly specific for divalent cations and more effective than A23187 (Cat. No. 100105) as a mobile ion carrier for Ca2+.

Quality Segment

100

description

RTECS - NO0600000

assay

≥90% (HPLC)

form

waxy solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

solubility

DMSO: 10 mg/mL, methanol: 10 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33?,36+,37?,39-,40+,41+/m1/s1

InChI key

PGHMRUGBZOYCAA-OJFQOPKISA-N

General description

Absorption max. (280 nm, MeOH): 18,600 M-1cm-1.
Highly specific for divalent cations (Ca2+ > Mg2+ >> Sr2+ = Ba2+). More effective than antibiotic A23187 as a mobile ion carrier for Ca2+. Complexes with Ca2+ between pH 7 and 9.5, causing significant absorption in the UV range; however, in contrast to A23187 (Cat. No. 100105), it is not fluorescent. Useful for studies of Ca2+ transport across biological membranes and measurement of cytoplasmic free Ca2+. Induces apoptotic neuronal degeneration in embryonic cortical neurons. Also induces cell cycle arrest in the G1 interval of mature Burkitt lymphoma cell lines.
Highly specific for divalent cations and more effective than A23187 (Cat. No. 100105) as a mobile ion carrier for Ca2+. Complexes with Ca2+ between pH 7 and 9.5. In contrast to A23187, it is not fluorescent. Useful for studies of Ca2+ transport across biological membranes and measurement of cytoplasmic free Ca2+. Induces apoptotic neuronal degeneration in embryonic cortical neurons and cell cycle arrest in the G1 phase in mature Burkitt lymphoma cell lines.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Mobile ion carrier for Ca2+
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, store in the refrigerator (4°C).

Other Notes

Aagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol.155, 3297.
Takei, N., and Endo, Y. 1994. Brain Res. 652, 65.
Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol.154, 44.
Lee, H.C. 1993. J. Biol. Chem.268, 293.
Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932.
Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc.101, 3344.
Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem.253, 5892.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

Storage Class

10 - Combustible liquids

Regulatory Information

涉药品监管产品

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Certificates of Analysis (COA)

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Global Trade Item Number

SKUGTIN
407950-5MG04055977211573
407950-10MG04055977211566
407950-1MG04055977211559