Isohelenin, Inula sp. - Calbiochem

A cell-permeable sesquiterpene lactone with anti-inflammatory properties. Acts as a highly specific, potent, and irreversible inhibitor of NF-κB activation by preventing IκBα degradation. Does not affect the DNA binding activity of activated NF-κB or inhibit Fyn and Src kinase activities. Also reported to inhibit IL-8 gene expression in cultured human respiratory epithelium and iNOS gene expression in cultured rat aortic smooth muscle cells. Shown to protect against endotoxic shock in rats.

A cell-permeable sesquiterpene lactone with anti-inflammatory properties. Acts as a highly specific, potent, irreversible inhibitor of NF-κB activation that acts by preventing IκBα degradation. Does not affect the DNA binding activity of activated NF-κB, or inhibit p59^fyn and Src kinase activities. Inhibits IL-8 gene expression in cultured human respiratory epithelium in vitro, and iNOS gene expression in cultured rat aortic smooth muscle cells. Offers protection against endotoxic shock in vivo.

Cell permeable: yes

Primary Target
NF-κB activation

Product does not compete with ATP.

Reversible: no

Packaged under inert gas

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Sheehan, M., et al. 2002. J. Endotoxin. Res.8, 99.
Mazor, R.L., et al. 2000. Cytokine12, 239.
Wong. H.R., and Menendez, I.Y., 1999. Biochem. Biophys. Res. Commun.262, 375.
Hehner, S.P., et al. 1998. J. Biol. Chem.273, 1288.
Bork, P.M., et al. 1997. FEBS Lett.402, 85.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Standard Handling (A)