420326
IRTK Activator III, DDN
The IRTK Activator III, DDN modulates the biological activity of IRTK. This small molecule/inhibitor is primarily used for Biochemicals applications.
Synonym(s):
IRTK Activator III, DDN, 5,8-Diacetyloxy-2,3-dichloro-1,4-naphthoquinone
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About This Item
Empirical Formula (Hill Notation):
C14H8Cl2O6
CAS Number:
Molecular Weight:
343.12
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
Storage condition:
OK to freeze, desiccated, protect from light
Quality Level
assay
≥98% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated, protect from light
color
pale yellow-green
solubility
DMSO: 25 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
An orally bioavilable diacetyloxy-naphthoquinone compound that directly targets insulin receptor tyrosine kinase (IRTK) domain and specifically increases IR kinase activity with no effect on IGF-1R and EGFR. Shown to rapidly phosphorylate IR (Tyr1146 and Tyr1158/1162/1163) and IRS-1 and selectively activate insulin signaling Akt (Thr473) and ERK pathways in CHO-IGF-IR cells at 5 µM. Sensitizes insulin action, enhances glucose uptake in differentiated 3T3-L1 adipocytes and decreases blood glucose levels in both normal and diabetic C57BL/6J mice (20 mg/kg, p.o.).
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
He, K., et al. 2011. J. Biol. Chem.286, 37379.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
Regulatory Information
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 420326-25MG | 04055977187489 |