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Merck
CN

434692

Sigma-Aldrich

Leukotriene C₄ - CAS 72025-60-6 - Calbiochem

Synonym(s):

Leukotriene C₄ - CAS 72025-60-6 - Calbiochem, LTC₄, 5(S)-Hydroxy-6(R)-S-glutathionyl-7- trans-9- trans-11- cis-14- cis-eicosatetraenoic Acid

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About This Item

Empirical Formula (Hill Notation):
C30H47N3O9S
CAS Number:
72025-60-6
Molecular Weight:
625.77
MDL number:
MFCD00151079
UNSPSC Code:
12352211

Key Documents

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Assay

≥98% (HPLC)

Quality Level

100

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

shipped in

wet ice

storage temp.

−70°C

InChI

1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1

InChI key

GWNVDXQDILPJIG-NXOLIXFESA-N

General description

This product has been discontinued.



Implicated in renal vasoconstriction associated with sepsis. Also plays a role in bronchioconstriction. Produced by conjugation of LTA4 with reduced glutathione. Reported to be a tight binding inhibitor of microsomal glutathione transferase-1. Has been implicated in pathophysiology of asthma.

Implicated in renal vasoconstriction associated with sepsis. Also plays a role in bronchioconstriction. Produced by conjugation of LTA4 with reduced glutathione. Reported to be a tight binding inhibitor of microsomal glutathione transferase-1. Has been implicated in pathophysiology of asthma.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Microsomal glutathione transferase-1
Product does not compete with ATP.
Reversible: no

Physical form

In MeOH:NH₄OAc buffer (65:35), pH 5.6.

Preparation Note

Following initial thaw, aliquor and freeze (-70°C).

Other Notes

Bannenberg, G., et al. 1999. J. Biol. Chem. 274, 1994.
Shimizu, T., et al. 1994. Pediatr. Pulmonol. 18, 129.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Flammable (J)

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes,Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Regulatory Information

新产品
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