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Merck
CN

444144

MDM2 Antagonist II, NSC 66811

The MDM2 Antagonist II, NSC 66811, also referenced under CAS 6964-62-1, controls the biological activity of MDM2.

Synonym(s):

MDM2 Antagonist II, NSC 66811, 7-(Anilino(phenyl)-methyl)-2-methyl-8-quinolinol, MDM2 Inhibitor II

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About This Item

CAS Number:
6964-62-1
UNSPSC Code:
12352200

Key Documents

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Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 10 mg/mL

storage temp.

2-8°C

InChI

1S/C23H20N2O/c1-16-12-13-18-14-15-20(23(26)22(18)24-16)21(17-8-4-2-5-9-17)25-19-10-6-3-7-11-19/h2-15,21,25-26H,1H3

InChI key

WEENRMPCSWFMTE-UHFFFAOYSA-N

General description

A cell-permeable, non-peptidyl, quinolinol compound that binds MDM2 with high affinity (Ki = 120 nM) and disrupts MDM2-p53 interaction. Shown to dose-dependently induce cellular accumulation of p53, MDM2, and p21 in HCT-116 human colon cancer cell line with wild-type p53.
The MDM2 Antagonist II, NSC 66811, also referenced under CAS 6964-62-1, controls the biological activity of MDM2.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
MDM2
Product does not compete with ATP.
Target Ki: 120 nM against MDM2

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Lu, Y., et al. 2006. J. Med. Chem.49, 3759.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

新产品
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Certificates of Analysis (COA)

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Yipin Lu et al.
Journal of medicinal chemistry, 49(13), 3759-3762 (2006-06-23)
An integrated, virtual database screening strategy has led to 7-[anilino(phenyl)methyl]-2-methyl-8-quinolinol (4, NSC 66811) as a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. This quinolinol binds to MDM2 with a Ki of 120 nM and activates p53 in

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