444237
MMP-8 Inhibitor I - CAS 236403-25-1 - Calbiochem
The MMP-8 Inhibitor I, also referenced under CAS 236403-25-1, controls the biological activity of MMP-8. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Synonym(s):
MMP-8 Inhibitor I - CAS 236403-25-1 - Calbiochem, (3R)-(+)-[2-(4-Methoxybenzenesulfonyl)-1,2,3,4-tetrahydroisoquinoline-3-hydroxamate]
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About This Item
Empirical Formula (Hill Notation):
C17H18N2O5S
CAS Number:
Molecular Weight:
362.40
UNSPSC Code:
12352200
assay
≥95% (HPLC)
form
solid
potency
4 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 200 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
A cell-permeable, potent inhibitor of MMP-8 (neutrophil collagenase; IC50 = 4 nM).
A potent and cell-permeable inhibitor of MMP-8 (IC50 = 4 nM).
Biochem/physiol Actions
Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Other Notes
Prager, G.W., et al. 2004. Blood103, 955.
Matter, H., et al. 1999. J. Med. Chem.42, 1908.
Matter, H., et al. 1999. J. Med. Chem.42, 1908.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Chengxin Zhang et al.
Cells, 11(20) (2022-10-28)
Aortic dissection (AD) is a lethal aortic pathology without effective medical treatments since the underlying pathological mechanisms responsible for AD remain elusive. Matrix metalloproteinase-8 (MMP8) has been previously identified as a key player in atherosclerosis and arterial remodeling. However, the
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