444286-M
MMP-2 Inhibitor II
The MMP-2 Inhibitor II, also referenced under CAS 869577-51-5, controls the biological activity of MMP-2. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Synonym(s):
MMP-2 Inhibitor II, (4-(4-(Methanesulfonamido)phenoxy)phenylsulfonyl)methyloxirane
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C16H17NO6S2
CAS Number:
Molecular Weight:
383.44
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated, protect from light
Quality Segment
assay
≥97% (HPLC)
form
solid
potency
2.4 μM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated, protect from light
color
white
solubility
DMSO: 200 mg/mL
storage temp.
−20°C
SMILES string
[S](=O)(=O)(Nc1ccc(cc1)Oc2ccc(cc2)[S](=O)(=O)CC3OC3)C
InChI
1S/C16H17NO6S2/c1-24(18,19)17-12-2-4-13(5-3-12)23-14-6-8-16(9-7-14)25(20,21)11-15-10-22-15/h2-9,15,17H,10-11H2,1H3
InChI key
ADEXXMLIERNFQB-UHFFFAOYSA-N
General description
An oxirane analog of SB-3CT, pMS (Cat. No. 444285) that acts as a selective, active site-binding, irreversible inhibitor of MMP-2 (Ki = 2.4 µM). Although less potent, it exhibits enhanced selectivity towards MMP-2 (Ki = 45 and 379 µM for MMP-1 and MMP-7, respectively) than SB-3CT, pMS.
Biochem/physiol Actions
Secondary Target
MMP-2 (Ki = 45 and 379 µM for MMP-1 and MMP-7, respectively)
MMP-2 (Ki = 45 and 379 µM for MMP-1 and MMP-7, respectively)
Other Notes
Ikejiri, M., et al. 2005. J. Biol. Chem.280, 33992.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.