448105
c-Met Kinase Inhibitor III
The c-Met Kinase Inhibitor III controls the biological activity of c-Met.
Synonym(s):
c-Met Kinase Inhibitor III, 2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)cyclopropanecarboxamide
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About This Item
Empirical Formula (Hill Notation):
C21H17Cl2FN2O2
Molecular Weight:
419.28
UNSPSC Code:
12352200
Quality Level
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 50 mg/mL
shipped in
wet ice
storage temp.
−20°C
General description
A 6-Benzyloxyquinoline derivative which acts as an ATP-competitive inhibitor against c-Met (IC50 = 9.3 nM), with more than 20 fold selectivity against a panel of 19 receptor tyrosine kinases and 8 serine/threonine kinases, in enzymatic assays. Also exhibits MKN45 cell growth inhibition (IC50 = 93 nM) and displays HDG-dependent anti-proliferative activity (IC50 = 300 nM) in HUVEC cultures, in vitro.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Nishii, H., et al. 2009. Bioorg. Med. Chem. Lett.20, 1405.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 448105-2MG | 04055977204674 |