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475843

Minocycline, Hydrochloride - CAS 13614-98-7 - Calbiochem

Name: Minocycline, Hydrochloride - CAS 13614-98-7 - Calbiochem
Brand: MM

Semi-synthetic tetracycline derivative effective against tetracycline-resistant staphylococci.

Synonym(s):

Minocycline, Hydrochloride - CAS 13614-98-7 - Calbiochem, 7-Dimethylamino-6-demethyl-6-deoxytetracycline, HCl

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₂₇N₃O₇ · xHCl

CAS Number:

13614-98-7

Molecular Weight:

457.48 (free base basis)

UNSPSC Code:

12352200

MDL number:

MFCD00083669

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Properties

Quality Level

100

assay

≥98% (TLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

dark yellow

solubility

water: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C23H27N3O7.ClH/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28;/h5-6,9,11,17,27-28,32-33H,7-8,24H2,1-4H3;1H/b22-16-;/t9-,11-,17-,23-;/m0./s1

InChI key

KDLQIOPKJDNQIM-WUURTAMISA-N

Description

General description

Semi-synthetic tetracycline derivative effective against tetracycline-resistant staphylococci. A matrix metalloproteinase (MMP) inhibitor shown to inhibit tumor-induced angiogenesis. Inhibits stromelysin (MMP-3; IC₅₀ = 290 µM) but does not inhibit other MMPs such as fibroblast collagenase or gelatinase. Potently inhibits PARP-1 (K_i = 13.4 nM) in a NAD⁺ - competitive manner. Exhibits anti-inflammatory effects and suppresses T cell proliferation.

This product has been discontinued.

Semi-synthetic tetracycline derivative effective against tetracycline-resistant staphylococci. A matrix metalloproteinase (MMP) inhibitor shown to inhibit tumor-induced angiogenesis. Inhibits stromelysin (MMP-3; IC₅₀ = 290 M) but does not inhibit other MMPs such as fibroblast collagenase or gelatinase. Potently inhibits PARP-1 (K_i = 13.4 nM) in a NAD⁺ - competitive manner. Exhibits anti-inflammatory effects and suppresses T cell proliferation.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Metalloproteinase (MMP)

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 290 µM against MMP-3

Target K_i: 13.4 nM against PARP-1

Other Notes

Conrad, C.A., et al. 2006. Proc. Natl. Acad, Sci. USA103, 9685.
Gilbertson-Breading, S., et al. 1995. Cancer Chemother. Pharmacol. 36, 418.
Kloppenburg, M., et al. 1995. Clin. Exp. Immunol. 102, 635.
Preus, H.R., et al. 1995. J. Clin. Periodontol. 22, 380.
Weingart, J.D., et al. 1995. J. Neurosurg. 82, 635.
Tamargo, R.J., et al. 1991. Cancer Res. 51, 672.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c