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Merck
CN
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About This Item

Empirical Formula (Hill Notation):
C30H20Cl2MnO6
Molecular Weight:
602.32
UNSPSC Code:
12352200
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Assay

≥98% (elemental analysis)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

pale yellow

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

This product has been discontinued.



A cell-permeable manganese complex of 7-hydroxyflavone that acts as a superoxide dismustase (SOD) mimetic and a neuroprotective agent against radical-induced damages. Shown to prevent the reduction of NBT by O2– • (IC50 = 1.18 µM) and exhibit ~10 times higher potency than Trolox (Cat. No. 648471) in inhibiting lipid peroxidation (IC50 = 6.15 µM) in vitro. Suppresses MAP (methamphetamine)-induced brain hypermotility in mice and shows protective effects against learning and memory impairment in a murine ischemic model in vivo.

A cell-permeable manganese complex of 7-hydroxyflavone that acts as a superoxide dismutase (SOD) mimetic and exhibits neuroprotective effects against radical-induced damage. Shown to prevent the reduction of NBT by O2− • (IC50 = 1.18 µM). Reported to exhibit ~10 times higher potency than Trolox (Cat. No. 648471) in inhibiting lipid peroxidation (IC50 = 6.15 µM) in vitro. Suppresses MAP (methamphetamine)-induced brain hypermotility in mice and shows protective effects against learning and memory impairment in a murine ischemic model.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Superoxide dismustase (SOD) mimetic
Product does not compete with ATP.
Reversible: no
Target IC50: 1.18 µM in preventing the reduction of NBT by O2- • in vitro

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Vajragupta, O., et al. 2003. Bioorg. Med. Chem.11, 2329.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

Storage Class Code

10-13 - German Storage Class 10 to 13

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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