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475870

MnTBAP

Name: MnTBAP
Brand: MM

≥95% (TLC), solid, SOD mimetic, Calbiochem^®

Synonym(s):

MnTBAP, Mn(III)tetrakis(4-benzoic acid)porphyrin Chloride

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About This Item

Empirical Formula (Hill Notation):

C₄₈H₂₈ClMnN₄O₈

CAS Number:

55266-18-7

Molecular Weight:

879.15

MDL number:

MFCD06227760

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥95% (TLC)

Form:

solid

Storage condition:

OK to freeze, desiccated, protect from light

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Properties

Product Name

MnTBAP, Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger.

Quality Segment

100

assay

≥95% (TLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated, protect from light

color

brown

solubility

aqueous base: soluble

shipped in

ambient

storage temp.

−20°C

SMILES string

[Mn]1([n]2c3c(c5nc(c(c7[n]1c(c(c9nc(c(c2cc3)c%10ccc(cc%10)C(=O)O)cc9)c8ccc(cc8)C(=O)O)cc7)c6ccc(cc6)C(=O)O)cc5)c4ccc(cc4)C(=O)O)Cl

InChI key

XHVDAQLNUQLQKW-PTJHDCLZSA-K

Description

General description

Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner (EC₅₀ ~40 µM) against paraquat (2 mM). Inhibits the oxidation of Dihydrorhodamine 123 (Cat. No. 309825) by peroxynitrite, but does not scavenge nitric oxide (NO).

Biochem/physiol Actions

Cell permeable: yes

EC50 ~40 µM in protecting endothelial cells against paraquat (2 mM)

Primary Target
Superoxide dismutase (SOD) mimetic

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Aladag, M. A., et al. 2003. Acta Neurochir.145, 673.
Szabo, C., et al. 1996. FEBS Lett. 381, 82.
Day, B.J., et al. 1995. J. Pharmacol. Exp. Ther. 275, 1227.
Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c