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Sigma-Aldrich

Monensin, Sodium Salt, High Purity

Polyether antibiotic that functions as a Na+ ionophore by forming stable complexes with monovalent cations that are able to cross the plasma membrane.

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Synonym(s):
Monensin, Sodium Salt, High Purity
Empirical Formula (Hill Notation):
C36H61O11 · Na
CAS Number:
22373-78-0
Molecular Weight:
692.85
MDL number:
MFCD00077826

Quality Level

100

Assay

≥97% (by Assay)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

off-white to beige

solubility

chloroform: soluble
ethanol: soluble
methanol: soluble

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C36H62O11.Na/c1-10-34(31-20(3)16-26(43-31)28-19(2)15-21(4)36(41,18-37)46-28)12-11-27(44-34)33(8)13-14-35(47-33)17-25(38)22(5)30(45-35)23(6)29(42-9)24(7)32(39)40;/h19-31,37-38,41H,10-18H2,1-9H3,(H,39,40);/q;+1/p-1/t19-,20-,21+,22+,23-,24-,25-,26+,27+,28-,29+,30-,31+,33-,34-,35+,36-;/m0./s1

InChI key

XOIQMTLWECTKJL-FBZUZRIGSA-M

General description

Polyether antibiotic that functions as a Na+ ionophore by forming stable complexes with monovalent cations that are able to cross the plasma membrane. Blocks glycoprotein secretion. Inhibits the ability of HDL to decrease cellular cholesterol esterification. Also reported to induce catecholamine secretion from adrenal chromaffin cells.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Functions as a Na+ ionophore
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Highly Toxic (H)

Reconstitution

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C. Unstable in acidic solutions.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Inabayashi, M., et al. 1995. Biochemistry34, 3455.
Mendez, A.J. 1995. J. Biol. Chem.270, 5891.
Sakuragawa, N., et al. 1994. Biochim. Biophys. Acta1213, 193.
Griffin, T., et al. 1993. J. Natl. Cancer Inst.85, 292.
Rushfeldt, C., and Smedsrtod, B. 1993. Cancer Res.53, 658.
Hoya, A., and Venosa, R.A. 1992. Biochem. Biophys. Acta1104, 123.
Kok, J.W. 1992. J. Cell. Sci.103, 1139.
Takemura, H., and Ohshika, H. 1992. Biochem. Pharmacol.44, 1395.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Resp. Sens. 1 - STOT RE 2

Storage Class Code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(C)

Not applicable

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Bingqing Zheng et al.
International journal of molecular sciences, 22(14) (2021-07-25)
NK cells play crucial roles in defending against persistent HBV. However, NK cells present dysfunction in chronic hepatitis B virus (CHB) infection, and the associated mechanism is still not fully understood. Except for the regulatory receptors, NK cells could also

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