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Merck
CN

476480

PKC 20-28, Cell-Permeable, Myristoylated

Pseudosubstrate sequence from protein kinase Cα and β ( PKCα and PKCβ).

Synonym(s):

PKC 20-28, Cell-Permeable, Myristoylated, Myr-N-FARKGALRQ-NH2, Myristoylated Protein Kinase C Inhibitor 20-28, Cell-Permeable, Protein Kinase C 20-28, Cell-Permeable, Myristoylated, Myristoylated Protein Kinase C Inhibitor 20-28, Cell-Permeable, Myr-N-FARKGALRQ-NH2, Protein Kinase C 20-28, Cell-Permeable, Myristoylated

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About This Item

Empirical Formula (Hill Notation):
C60H106N18O11
Molecular Weight:
1255.60
UNSPSC Code:
12352200

Key Documents

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Quality Level

100

Assay

≥95% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

solubility

water: 10 mg/mL
Tris-HCl, pH 7.5: 25 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

Pseudosubstrate sequence from protein kinase Cα and β ( PKCα and PKCβ). N-Terminus is myristoylated to allow membrane permeability. Highly specific, reversible, and substrate competitive inhibitor of TPA activation of MARCKS phosphorylation in fibroblast primary cultures (IC50 = 8 µM); exhibits 98% inhibition at 100 µM.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
TPA activation of MARCKS phosphorylation in fibroblast primary cultures
Product does not compete with ATP.
Reversible: yes
Target IC50: 8 µM against TPA activation of MARCKS phosphorylation in fibroblast primary cultures

Packaging

Yes

Other Notes

Eichholtz, T., et al. 1993. J. Biol. Chem. 268, 1982.
Ward, N.E. and O’Brian, C.A. 1993. Biochemistry32, 11903.
N-Myr-Phe-Ala-Arg-Lys-Gly-Ala-Leu-Arg-Gln-NH₂

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Carsten Riether et al.
Cell reports, 34(4), 108663-108663 (2021-01-28)
Self-renewal is a key characteristic of leukemia stem cells (LSCs) responsible for the development and maintenance of leukemia. In this study, we identify CD93 as an important regulator of self-renewal and proliferation of murine and human LSCs, but not hematopoietic

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