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479830

NBI-31772 - CAS 374620-70-9 - Calbiochem

Synonym(s):

NBI-31772 - CAS 374620-70-9 - Calbiochem, [1-(3ʹ,4ʹ-Dihydroxybenzoyl)-6,7-dihydroxyisoquinoline-3-carboxylic Acid]

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About This Item

Empirical Formula (Hill Notation):
C17H11NO7
CAS Number:
374620-70-9
Molecular Weight:
341.27
UNSPSC Code:
12352200
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assay

≥95% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

green-yellow

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

This product has been discontinued.



We are offering NBI 31772 hydrate (Cat. No. N8289) as a possible alternative. Please read the alternative product documentation carefully and contact technical service if you need additional information.






A non-peptide ligand that exhibits high-affinity (Ki ~ 1 - 17 nM) towards all six human insulin-like growth factor-I binding proteins (IGFBPs). Displaces insulin-like growth factor-I (IGF-I) from the IGF-I:IGFBP complex in 3T3 fibroblasts; however, it does not interact with the IGF receptors.

A non-peptide ligand derived from the transformation of L-3,4-dihydroxy-phenylalanine that exhibits high affinity binding to all six human insulin-like growth factor-I binding proteins (IGFGPs) (Ki = 3.36 nM for IGFBP-1, 1.18 nM for IGFBP-2, 5.64 nM for IGFBP-3, 1.54 nM for IGFBP-4, 3.90 nM for IGFBP-5, and 16.6 nM for IGFBP-6). Inhibits insulin-like growth factor (IGF-I) induced cell proliferation in 3T3 fibroblasts through the displacement of IGF-I from the IGF-I:GFBP complex. However, it does not interact with IGF receptors.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Human insulin-like growth factor-I binding proteins (IGFBPs).
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Chen, C., et al. 2001. J. Med. Chem.44, 4001.
Liu, X.J., et al. 2001. J. Biol. Chem.276, 32419.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品

This item has

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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