488004
Nodinitib-1 - Calbiochem
Synonym(s):
Nodinitib-1 - Calbiochem, NOD1 Signaling Inhibitor, Nucleotide-binding Oligomerization Domain 1 Signaling Inhibitor, CID-1088438, 1-((4-Methylphenyl)sulfonyl)-1H-benzimidazol-2-amine, ML130, 1-(Toluene-4-sulfonyl)-1H-benzimidazol-2-ylamine
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About This Item
storage temp.
2-8°C
assay
≥99% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 50 mg/mL, clear, colorless
shipped in
ambient
Quality Level
General description
This product has been discontinued.
A cell-permeable aminobenzimidazole compound that acts as a potent, specific and reversible inhibitor of NOD1 (Nucleotide-binding Oligomerization Domain 1; NLRC1, CARD4, or CLR7.1)-induced NF-κB activation (IC50 = 0.56 µM, >20, and >20 by NOD1 ligand, NOD2 ligand and TNFα in HEK293T-NF-κB-luciferase cells, respectively). Shown to block phosphorylation and degradation of IκBα and MAPK signaling (5 µM in HCT-116 cells) with no effect on Akt pathway. Suggested to directly interact with NOD1, alter the conformation and suppress RIP2 trafficking, a NOD1-binding partner required for NF-κB induction.
Packaging
Preparation Note
Other Notes
Correa, R.G., et al. 2011. Chem. Biol.18, 825.
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Storage Class
10-13 - German Storage Class 10 to 13
Regulatory Information
Certificates of Analysis (COA)
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