Skip to Content
Merck
CN

488230

Sigma-Aldrich

Nogo-66 (1-40) Antagonist Peptide, Synthetic - Calbiochem

Synonym(s):

Nogo-66 (1-40) Antagonist Peptide, Synthetic - Calbiochem, Nogo Extracellular Peptide, 1-40, NEP1-40, Ac-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH₂

Sign Into View Organizational & Contract Pricing

Select a Size

About This Item

Empirical Formula (Hill Notation):
C206H324N56O65
Molecular Weight:
4625.11
UNSPSC Code:
12352200

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Assay

≥95% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

white

solubility

DMSO: 5 mg/mL

shipped in

wet ice

storage temp.

−20°C

General description

This product has been discontinued.



An end-protected 40-mer peptide derived from the N-terminal fragment of the Nogo-66 domain that acts as a selective, competitive, high affinity antagonist of Nogo-66 receptor (NgR). Although NgR serves as the common receptor for both Nogo-66 and MAG (myelin-associated glycoprotein), NEP1-40 blocks only the inhibition of neurite outgrowth induced by Nogo-66, but not that by MAG. Promotes axonal regeneration after spinal cord injury in rats.

An end-protected 40 amino acid peptide derived from the N-terminal fragment of the Nogo-66 domain that is normally expressed on the surface of oligodendrocytes. Acts as a selective, competitive, high affinity antagonist of Nogo-66 receptor (NgR). Although NgR serves as the common receptor for both Nogo-66 and myelin-associated glycoprotein (MAG), NEP1-40 blocks the inhibition of Nogo-66-induced neurite outgrowth, but not that of MAG. Promotes axonal regeneration following spinal cord injury in rats.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Nogo-66 receptor (NgR)
Product competes with ATP.
Reversible: no

Packaging

Packaged under inert gas

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Ac-Arg-Ile-Tyr-Lys-Gly-Val-Ile-Gln-Ala-Ile-Gln-Lys-Ser-Asp-Glu-Gly-His-Pro-Phe-Arg-Ala-Tyr-Leu-Glu-Ser-Glu-Val-Ala-Ile-Ser-Glu-Glu-Leu-Val-Gln-Lys-Tyr-Ser-Asn-Ser-NH₂
GrandPré, T., et al. 2002. Nature417, 547.
Liu, B.P., et al. 2002. Science297, 1190.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品
This item has

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service