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Merck
CN

488230

Nogo-66 (1-40) Antagonist Peptide, Synthetic - Calbiochem

Synonym(s):

Nogo-66 (1-40) Antagonist Peptide, Synthetic - Calbiochem

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About This Item

Empirical Formula (Hill Notation):
C206H324N56O65
Molecular Weight:
4625.11
UNSPSC Code:
12352200

Key Documents

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assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

white

solubility

DMSO: 5 mg/mL

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

General description

This product has been discontinued.



An end-protected 40-mer peptide derived from the N-terminal fragment of the Nogo-66 domain that acts as a selective, competitive, high affinity antagonist of Nogo-66 receptor (NgR). Although NgR serves as the common receptor for both Nogo-66 and MAG (myelin-associated glycoprotein), NEP1-40 blocks only the inhibition of neurite outgrowth induced by Nogo-66, but not that by MAG. Promotes axonal regeneration after spinal cord injury in rats.

An end-protected 40 amino acid peptide derived from the N-terminal fragment of the Nogo-66 domain that is normally expressed on the surface of oligodendrocytes. Acts as a selective, competitive, high affinity antagonist of Nogo-66 receptor (NgR). Although NgR serves as the common receptor for both Nogo-66 and myelin-associated glycoprotein (MAG), NEP1-40 blocks the inhibition of Nogo-66-induced neurite outgrowth, but not that of MAG. Promotes axonal regeneration following spinal cord injury in rats.

Biochem/physiol Actions

Primary Target
Nogo-66 receptor (NgR)
Product competes with ATP.
Reversible: no
Cell permeable: no

Packaging

Packaged under inert gas

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Ac-Arg-Ile-Tyr-Lys-Gly-Val-Ile-Gln-Ala-Ile-Gln-Lys-Ser-Asp-Glu-Gly-His-Pro-Phe-Arg-Ala-Tyr-Leu-Glu-Ser-Glu-Val-Ala-Ile-Ser-Glu-Glu-Leu-Val-Gln-Lys-Tyr-Ser-Asn-Ser-NH₂
GrandPré, T., et al. 2002. Nature417, 547.
Liu, B.P., et al. 2002. Science297, 1190.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

监管及禁止进口产品
This item has

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