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Sigma-Aldrich

Omi/HtrA2 Protease Inhibitor, Ucf-101

The Omi/HtrA2 Protease Inhibitor, Ucf-101, also referenced under CAS 313649-08-0, controls the biological activity of Omi/HtrA2 Protease. This small molecule/inhibitor is primarily used for Cancer applications.

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Synonym(s):
Omi/HtrA2 Protease Inhibitor, Ucf-101, High Temperature Requirement A2 Inhibitor I, 5-[5-(2-Nitrophenyl)furfurylidine]-1,3-diphenyl-2-thiobarbituric Acid
Empirical Formula (Hill Notation):
C27H17N3O5S
CAS Number:
313649-08-0
Molecular Weight:
495.51
MDL number:
MFCD01000361

Quality Level

100

Assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

orange

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C27H19N3O5S/c31-25-22(17-20-15-16-24(35-20)21-13-7-8-14-23(21)30(33)34)26(32)29(19-11-5-2-6-12-19)27(36)28(25)18-9-3-1-4-10-18/h1-17,33-34H

InChI key

QMGXAGWZCHDZRG-UHFFFAOYSA-N

General description

A cell-permeable furfurylidine-thiobarbituric acid compound that acts as a potent, specific, competitive, and reversible inhibitor of the pro-apoptotic, heat-inducible, mitochondrial serine protease Omi/HtrA2 (IC50 = 9.5 µM for His-Omi134-458). Shows very little activity against various other serine proteases tested (IC50 ≥ 200 µM). Reported to block Omi/HtrA2 induced cell death in caspase-9 (-/-) null fibroblasts.
A cell-permeable, furfurylidine-thiobarbituric acid compound that acts as a potent, specific, competitive, and reversible inhibitor of the pro-apoptotic, heat-inducible, mitochondrial serine protease, Omi/HtrA2 (IC50 = 9.5 µM for His-Omi134-458). Reported to inhibit Omi/HtrA2-induced cell death in caspase-9 (-/-) null fibroblasts. Does not significantly inhibit other serine proteases, including kallikrein, trypsin, plasmin, thrombin, and tissue plasminogen activator (t-PA) (IC50 ≥200 µM).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
pro-apoptotic, heat-inducible, mitochondrial serine protease Omi/HtrA2
Product does not compete with ATP.
Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Cilenti, L., et al. 2003. J. Biol. Chem.278, 11489.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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