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5.00500

MALT1 Inhibitor II, Mepazine Hydrochloride

Synonym(s):

MALT1 Inhibitor II, Mepazine Hydrochloride, 10-((1-Methylpiperidin-3-yl)methyl)-10H-phenothiazine, Hydrochloride, 10-((1-Methyl-3-piperidyl)methyl)phenothiazine, Hydrochloride, 10-((1-Methyl-3-piperidinyl)methyl)-10H-phenothiazine, Hydrochloride, MALT-1 Inhibitor II, Mucosa-Associated Lymphoid tis

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About This Item

Empirical Formula (Hill Notation):
C19H23ClN2S
CAS Number:
2975-36-2
Molecular Weight:
346.92
MDL number:
MFCD31657511
UNSPSC Code:
12352200
NACRES:
NA.77
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assay

≥97% (HPLC)

Quality Segment

100

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

gray to off-white

solubility

H2O: 2.5 mg/mL, DMSO: 25 mg/mL

storage temp.

−20°C

InChI

1S/C19H22N2S.Cl/c1-20-12-6-7-15(13-20)14-21-16-8-2-4-10-18(16)22-19-11-5-3-9-17(19)21;/h2-5,8-11,15H,6-7,12-14H2,1H3;

InChI key

ZGQUIYCUOPQIDJ-UHFFFAOYSA-N

General description

Mepazine hydrochloride is a cell-permeable phenothiazine derivative that inhibits mucosa-associated lymphoid tis 1(MALT1). It does not inhibit the caspase 3 or 8 proteolytic activity in a reversible and non-competitive manner. It blocks anti-CD3/CD28-stimulated IL-6 production in primary murine CD4+ T-cell and human peripheral blood mononuclear cell (PBMC) cultures. Mepazine has been observed to inhibit the MALT1 activity in activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL)and RelB cleavage, resulting in effective blockage of nuclear factor (NF-κB)-dependent interleukin-6, 10 as well as anti-apoptoticB-cell lymphoma - extra-large (Bcl-xL) and FLIP-L expression. Mepazineshows ABC-DLBCL-selective cytotoxicity over GCB-DLBCL both in cultures in vitro and in mice in vivo.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
MALT1

Physical form

Supplied as a hydrochloride salt.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

The molecular weight for this compound isbatch-specific due to variable water content. Please refer to the vial label orthe certificate of analysis for the batch-specific molecular weight. Themolecular weight provided represents the baseline molecular weight withoutwater.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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