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About This Item
Empirical Formula (Hill Notation):
C29H34ClN3O
CAS Number:
Molecular Weight:
476.05
MDL number:
UNSPSC Code:
12352200
Assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
off-white
solubility
DMSO: 20 mg/mL
storage temp.
−20°C
InChI
1S/C29H34ClN3O/c1-18-6-8-20(9-7-18)17-33-25(21-10-11-23(30)19(2)14-21)15-24(32-33)26(34)31-27-28(3,4)22-12-13-29(27,5)16-22/h6-11,14-15,22,27H,12-13,16-17H2,1-5H3,(H,31,34)/t22-,27-,29+/m1/s1
InChI key
SUGVYNSRNKFXQM-XRHWURSXSA-N
General description
A selective inverse agonist for peripheral cannabinoid (CB2) receptors (Ki = 0.6 nM and 400 nM for CB2 and CB1 receptors, respectively). Has been used in studies related to control of pain initiation, suppression of inflammation, and immune activation.
Biochem/physiol Actions
Primary Target
CB₂ Receptor
CB₂ Receptor
Target Ki: 0.6 nM and 400 nM for CB₂ and CB₁ receptors, respectively.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Barth, F., et al. 1999. Curr. Med. Chem.6, 745.
Iwamura, H., et al. 2001. J. Pharmacol. Exp. Ther.296, 420.
Wright, K., et al. 2008. Br. J. Pharmacol.153, 263.
Di Marzo, V. 2008. Nat. Rev. Drug Discov.7, 438.
Rinaldi-Carmona, M., et al. 1998. J. Pharmacol. Exp. Ther.284, 644.
Portier, M., et al. 1999. J. Pharmacol. Exp. Ther.288, 582.
Iwamura, H., et al. 2001. J. Pharmacol. Exp. Ther.296, 420.
Wright, K., et al. 2008. Br. J. Pharmacol.153, 263.
Di Marzo, V. 2008. Nat. Rev. Drug Discov.7, 438.
Rinaldi-Carmona, M., et al. 1998. J. Pharmacol. Exp. Ther.284, 644.
Portier, M., et al. 1999. J. Pharmacol. Exp. Ther.288, 582.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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