Skip to Content
Merck
CN

5.04317

Sigma-Aldrich

5-Azacytidine - CAS 320-67-2 - Calbiochem

Synonym(s):

5-Azacytidine - CAS 320-67-2 - Calbiochem, 5′AzaC, 5-Azacitidine, Zcyd, 4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one

Sign Into View Organizational & Contract Pricing

Select a Size

About This Item

Empirical Formula (Hill Notation):
C8H12N4O5
CAS Number:
320-67-2
Molecular Weight:
244.20
MDL number:
MFCD00006539
UNSPSC Code:
12352200

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Assay

≥93% (HPLC)

Quality Level

100

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

off-white

solubility

water: 10 mg/mL
DMSO: 100 mg/mL

storage temp.

2-8°C

InChI

1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1

InChI key

NMUSYJAQQFHJEW-KVTDHHQDSA-N

General description

This product has been discontinued.



A cell-permeable ribonucleoside analog of cytidine that is reported to readily incorporate into RNA and DNA, and inhibit protein synthesis. Causes DNA methyltransferases depletion, DNA hypomethylation and DNA damage. Selectively activates eukaryotic gene expression, and potently arrests the growth of several AML cells (EC50<4.0 µM). Enhances reprogramming efficiency (EC50 ~ 2.4 µM in iOSKM-MEFs). 5-Aza-2′-Deoxycytidine (ZaCyd) is also available (Cat. No. 189825) & (Cat. No. 189826).

A cell-permeable ribonucleoside analog of cytidine that is reported to readily incorporate into RNA and DNA, and inhibit protein synthesis. Causes DNA methyltransferases depletion, DNA hypomethylation and DNA damage. Selectively activates eukaryotic gene expression, and potently arrests the growth of several AML cells (EC50<4.0 µM). Enhances reprogramming efficiency (EC50 ~ 2.4 µM in iOSKM-MEFs). 5-Aza-2′-Deoxycytidine (ZaCyd) is also available (Cat. No. 189825) & (Cat. No. 189826).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
DNA & RNA
Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Unstable in H₂O. Following reconstitution, store at 4°C for <12 hr.

Other Notes

Hollenbach, P.W., et al. 2010. PLoS ONE5, e9001.
Mikkelsen, T.S., et al. 2008. Nature454, 49.
Huangfu, D., et al. 2008. Nat. Biotech.26, 795.
Christman, J.K., 2002. Oncogene 21, 5483.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

Regulatory Information

新产品
This item has

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service