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Merck
CN

5.04345

Sigma-Aldrich

BX471

Synonym(s):

BX471, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea, ZK-811752

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About This Item

Empirical Formula (Hill Notation):
C21H24ClFN4O3
CAS Number:
217645-70-0
Molecular Weight:
434.89
UNSPSC Code:
12352200

Key Documents

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Assay

≥98% (HPLC)

Quality Level

100

form

powder

potency

1-5 nM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white to beige

solubility

DMSO: ≥25 mg/mL

storage temp.

2-8°C

InChI

1S/C21H24ClFN4O3/c1-14-11-26(12-15-2-5-17(23)6-3-15)8-9-27(14)20(28)13-30-19-7-4-16(22)10-18(19)25-21(24)29/h2-7,10,14H,8-9,11-13H2,1H3,(H3,24,25,29)/t14-/m1/s1

InChI key

XQYASZNUFDVMFH-CQSZACIVSA-N

General description

An orally active, selective antagonist for chemokine receptor 1 (CCR-1) (Ki = 1-5 nM). Has been used in studies related to intracellular calcium mobilization and migration of leukocytes mediated through CCR-1.

Biochem/physiol Actions

Primary Target
CCR1

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Shahlaei, M., et al. 2011. J. Chemical Information and Modeling.51, 2717.

Reuss, R., et al. 2010. Mult Scler.16, 366.

Gladue, R., et al. 2010. Curr Top Med Chem10, 1268.

Vandemeulebroecke; M., et al. 2009. British J. of Clinical Pharmacol.68, 435.

Richard Horuk, R. 2005. Mini-Reviews in Medicinal Chemistry.5, 791.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(C)

Not applicable

Regulatory Information

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