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About This Item
Empirical Formula (Hill Notation):
C10H11NO4
CAS Number:
Molecular Weight:
209.20
MDL number:
UNSPSC Code:
12352200
Assay
≥99% (HPLC)
Quality Level
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
DMSO: 10 mM
H2O: 10 mM
storage temp.
2-8°C
InChI
1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15)/p-1/t10-/m0/s1
InChI key
DNCAZYRLRMTVSF-JTQLQIEISA-M
General description
A non-selective antagonist for group I/II mGlu receptors (minimal values of IC50 reported = 40 and 15 µM for mGlu1 and mGlu2, respectively). Often used as an agent to differentiate excitatory neurotransmissions mediated by glutamate from other neurotransmitters (i.e. dopamine, acetylcholine, and GABA in early brain development). A common component of cocktails for blocking glutamate transmission in brain slice preparation.
Biochem/physiol Actions
Primary Target
Grup I and II mGlu receptors
Grup I and II mGlu receptors
Target IC50: 40 and 15 →M for mGlu₁ and mGlu₂, respectively.
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Fano, S., et al. 2012. Eur. J. Neurosci.36, 3628.
Wang, W., et al. 2012. J. Physiol.590, 3743.
Cortes, C., et al. 2013. Synapse. DOI: 10.1002/syn.21646.Schoepp, D.D., et al. 1999.
Neuropharmacol.38, 1431.
Wang, W., et al. 2012. J. Physiol.590, 3743.
Cortes, C., et al. 2013. Synapse. DOI: 10.1002/syn.21646.Schoepp, D.D., et al. 1999.
Neuropharmacol.38, 1431.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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