Sign Into View Organizational & Contract Pricing
About This Item
Empirical Formula (Hill Notation):
C13H13NO4
CAS Number:
Molecular Weight:
247.25
MDL number:
UNSPSC Code:
12352200
Assay
≥98% (HPLC)
Quality Level
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
DMSO: 100 mM
storage temp.
2-8°C
InChI
1S/C13H13NO4/c1-2-17-12(15)13-7-9(13)11(14-16)8-5-3-4-6-10(8)18-13/h3-6,9,16H,2,7H2,1H3/b14-11-
InChI key
FXCTZFMSAHZQTR-KAMYIIQDSA-N
General description
A potent, negative allosteric modulator selective for mGlu1 receptors (IC50 = 6.5 µM). No effect on other mGlu subtype receptors and ionotropic glutamate receptors at concentrations less than 100 µM. Acts by inhibiting an intramolecular interaction between the agonist-bound extracellular domain and the transmembrane domain. Widely used for studies related to peripheral pain and central pain pathways.
Biochem/physiol Actions
Primary Target
mGlu₁ receptors
mGlu₁ receptors
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Luongo L, et al. 2013. Neuropharmacol.66, 317.
Jin, Y., et al. 2012. Pain Res. Treat.2012, 915706.
Tappe-Theodor, A., 2011. Mol Pain.7, 38.
Litschig, S., et al. 1999. Mol. Pharmacol.55, 453.
Annoura, H., et al. 1996. Bioorg. Med. Chem. Lett.6, 763.
Jin, Y., et al. 2012. Pain Res. Treat.2012, 915706.
Tappe-Theodor, A., 2011. Mol Pain.7, 38.
Litschig, S., et al. 1999. Mol. Pharmacol.55, 453.
Annoura, H., et al. 1996. Bioorg. Med. Chem. Lett.6, 763.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service