5.04839
(R)-CPP - CAS 126453-07-4 - Calbiochem
Synonym(s):
(R)-CPP - CAS 126453-07-4 - Calbiochem, (R)-3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid
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About This Item
Empirical Formula (Hill Notation):
C8H17N2O5P
CAS Number:
Molecular Weight:
252.20
UNSPSC Code:
12352200
assay
≥98% (NMR)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
water: 100 mM
storage temp.
2-8°C
General description
A highly potent antagonist slightly selective for NR2A over other subtype NMDA receptors (Ki = 0.041, 0.27, 0.63 and 1.99 µM for NMDA subtypes NR2A, NR2B, NR2C, and NR2D, respectively). Commonly used for various research in brain functions and disorders that neurotransmissions via NMDA receptors are involved.
Biochem/physiol Actions
Primary Target
NMDA receptors
NMDA receptors
Target Ki: 0.041, 0.27, 0.63 and 1.99 →M for NMDA subtypes NR2A, NR2B, NR2C, and NR2D, respectively.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Murphy, R., et al. 2012. Psychopharmacol.219, 401.
Paoletti, P., et al. 2007. Curr. Opin. Pharmacol.7, 47.
Feng, B., et al. 2004. Br. J. Pharmacol.141, 508.
Lowe, A., et al. 1990. Neurosci. Lett.113, 315.
Paoletti, P., et al. 2007. Curr. Opin. Pharmacol.7, 47.
Feng, B., et al. 2004. Br. J. Pharmacol.141, 508.
Lowe, A., et al. 1990. Neurosci. Lett.113, 315.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Regulatory Information
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