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About This Item
Empirical Formula (Hill Notation):
C8H15N2O5P
CAS Number:
Molecular Weight:
250.19
UNSPSC Code:
12352200
NACRES:
NA.77
Assay
≥99% (HPLC)
Quality Level
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
H2O: 100 mM
storage temp.
2-8°C
InChI
1S/C8H15N2O5P/c11-8(12)7-6-10(4-2-9-7)3-1-5-16(13,14)15/h1,5,7,9H,2-4,6H2,(H,11,12)(H2,13,14,15)/b5-1+/t7-/m1/s1
InChI key
VZXMZMJSGLFKQI-ABVWVHJUSA-N
General description
A highly potent competitive antagonist of NMDA receptors (ED50 = 39 nM; pA2 = 6.8). Biologically active admitted systemically. Frequently used in assessing the functional roles of NMDA receptors mediated neurotransmissions in a variety of research areas, such as excitotoxic cell death, apoptosis, bipolar disorders, ischemia, traumatic brain injury, epilepsy, and neuropathic pain.
Biochem/physiol Actions
Primary Target
NMDA receptors
NMDA receptors
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Lowe, D., et al. 1990. Neurosci. Lett.113, 315.
Bullock, R., et al. 1990. Stroke.21, 32.
Bespalov, A., et al. 1998. Eur. J. Pharmacol.351, 299.
Lowe, D., et al. 1994. Neurochem. Inter.25, 583.
Duty, S. 2012. CNS Drugs26, 1017.
Bullock, R., et al. 1990. Stroke.21, 32.
Bespalov, A., et al. 1998. Eur. J. Pharmacol.351, 299.
Lowe, D., et al. 1994. Neurochem. Inter.25, 583.
Duty, S. 2012. CNS Drugs26, 1017.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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