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Merck
CN

5.05278

PNU 282987

Synonym(s):

PNU 282987, PNU-282987, N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide hydrochloride, α7 nAChR Agonist, PNU 282987, alpha 7 Nicotinic Acetylcholine Receptor Agonist, PNU 282987, PNU282987

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About This Item

Empirical Formula (Hill Notation):
C14H17ClN2O · xHCl
CAS Number:
123464-89-1
Molecular Weight:
264.75 (free base basis)
UNSPSC Code:
12352200

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InChI key

HSEQUIRZHDYOIX-ZOWNYOTGSA-N

InChI

1S/C14H17ClN2O.ClH/c15-12-3-1-11(2-4-12)14(18)16-13-9-17-7-5-10(13)6-8-17;/h1-4,10,13H,5-9H2,(H,16,18);1H/t13-;/m0./s1

assay

≥99% (HPLC)

form

solid

potency

26 nM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

water: 100 mM

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Primary Target
α7 nAChRs
Reversible: yes

Disclaimer

Toxicity: Standard Handling (A)

General description

A potent agonist highly selective for α7 nAChRs (Ki = 26 nM). Used in investigating the roles of α7 nAChRs in sensory gating, learning and memory, cognitive functions, and treatment of Schizophrenia.

Other Notes

Hajós, M., et al., 2010, Curr. Pharm. Des.16, 538.
Bodnar, L., et al., 2005. J. Med. Chem.48, 905.
Hajós, M., et al., 2005. J. Pharmacol. Exp. Ther.312, 1213.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

Certificates of Analysis (COA)

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