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About This Item
Empirical Formula (Hill Notation):
C14H17ClN2O · xHCl
CAS Number:
Molecular Weight:
264.75 (free base basis)
UNSPSC Code:
12352200
Assay
≥99% (HPLC)
Quality Level
form
solid
potency
26 nM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
off-white
solubility
water: 100 mM
storage temp.
2-8°C
InChI
1S/C14H17ClN2O.ClH/c15-12-3-1-11(2-4-12)14(18)16-13-9-17-7-5-10(13)6-8-17;/h1-4,10,13H,5-9H2,(H,16,18);1H/t13-;/m0./s1
InChI key
HSEQUIRZHDYOIX-ZOWNYOTGSA-N
General description
A potent agonist highly selective for α7 nAChRs (Ki = 26 nM). Used in investigating the roles of α7 nAChRs in sensory gating, learning and memory, cognitive functions, and treatment of Schizophrenia.
Biochem/physiol Actions
Primary Target
α7 nAChRs
α7 nAChRs
Reversible: yes
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Hajós, M., et al., 2010, Curr. Pharm. Des.16, 538.
Bodnar, L., et al., 2005. J. Med. Chem.48, 905.
Hajós, M., et al., 2005. J. Pharmacol. Exp. Ther.312, 1213.
Bodnar, L., et al., 2005. J. Med. Chem.48, 905.
Hajós, M., et al., 2005. J. Pharmacol. Exp. Ther.312, 1213.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Certificates of Analysis (COA)
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