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Merck
CN

5.05626

(S)-Sulpiride

Synonym(s):

(S)-Sulpiride, (S)-(-)-5-Aminosulfonyl-N-[(1-ethyl­-2-pyrrolidinyl)methyl]-2-methoxybenzamide, D2-like dopamine antagonist, (s)-Sulpiride, Sulpiride

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About This Item

Empirical Formula (Hill Notation):
C15H23N3O4S
CAS Number:
23672-07-3
Molecular Weight:
341.43
UNSPSC Code:
12352200
MDL number:
MFCD00055220

Key Documents

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InChI

1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)

InChI key

BGRJTUBHPOOWDU-UHFFFAOYSA-N

assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 100 mM

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Primary Target
D2-like dopamine receptors

Disclaimer

Toxicity: Standard Handling (A)

General description

Dopamine D2 receptor antagonist with good aqueous solubility. S-sulpiride (200 nm) was used to confirm that dopamine currents were mediated through the D2 receptor in whole animal rat brain preps. IC50 of 0.01012 µM Antagonist activity at human dopamine D2 receptor expressed in CHOp cells assessed as inhibition of quinopirole-induced mitogenisis.

Other Notes

Eagle, D. M. et al. 2011. J. Neurosci.31, 7349.
Banala, A. K. et al. 2011. J. Med. Chem.54, 3581.
Seeman, P. and Van Tol, H. H. 1994. Trends Pharmacol. Sci.15, 264.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

Regulatory Information

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