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5.05771

Sigma-Aldrich

4-DAMP

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Synonym(s):
4-DAMP, 1,1-Dimethyl-4-diphenylacetoxypiper­idinium iodide, Muscarinic Receptor Antagonist, 4-DAMP
Empirical Formula (Hill Notation):
C21H26INO2
CAS Number:
1952-15-4
Molecular Weight:
451.34
MDL number:
MFCD00078564

Assay

≥98% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white to off-white

solubility

DMSO: 100 mM
ethanol: 25 mM

storage temp.

2-8°C

InChI

1S/C21H26NO2.HI/c1-22(2)15-13-19(14-16-22)24-21(23)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18;/h3-12,19-20H,13-16H2,1-2H3;1H/q+1;/p-1

InChI key

WWJHRSCUAQPFQO-UHFFFAOYSA-M

General description

An antagonist selective for mAChRs (Ki = 0.57, 7.3, 0.37, 0.72 and 0.55 nM at human M1, M2, M3, M4, and M5 receptors respectively). Used frequently in investigating the functional roles of M1 and M3 receptors in both central and peripheral nervous systems.

Biochem/physiol Actions

Primary Target
Muscarinic Receptors
Target Ki: 0.57, 7.3, 0.37, 0.72 and 0.55 nM at human M1, M2, M3, M4, and M5 receptors respectively

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Kruse, C., et al., 2012. Nature.482, 552.
Moriya, H., et al., 1999. Life Sci.64, 2351.
Ehlert, J., 1996. Life Sci.58, 1971.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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