5.05880
L-745,870 Trihydrochloride
Synonym(s):
L-745,870 Trihydrochloride, Dopamine D4 receptor Antagonist, L-745,870 trihydrochloride, L-745870, L745870
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About This Item
Empirical Formula (Hill Notation):
C18H19ClN4 · 3HCl
CAS Number:
Molecular Weight:
436.21
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
assay
≥99% (HPLC)
Quality Segment
form
solid
potency
0.4 nM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
water: soluble
storage temp.
2-8°C
SMILES string
Clc1ccc(cc1)N2CCN(CC2)Cc3c4c([nH]c3)nccc4
InChI
1S/C18H19ClN4/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18/h1-7,12H,8-11,13H2,(H,20,21)
InChI key
OGJGQVFWEPNYSB-UHFFFAOYSA-N
General description
Selective D4 receptor antagonist with excellent brain penetration. Displays an affinity (Ki) of 0.4 nM for human D4 receptors with >1000-fold binding selectivity over D2 and D3 receptors. Does not block agonist-induced activation of GIRK currents. It is used frequently in retinal and CNS studies of D4 modulation.
Biochem/physiol Actions
Primary Target
D₄
D₄
Reversible: yes
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Li, H. et al., 2013. J. Neurosci.33, 3135.
Pillai, G. et al. 1998. Neuropharmacol.337, 983.
Kulagowski, J. et al. 1996. J. Med. Chem.39, 1941.
Pillai, G. et al. 1998. Neuropharmacol.337, 983.
Kulagowski, J. et al. 1996. J. Med. Chem.39, 1941.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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