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Merck
CN

5.05895

CGP 35348

Synonym(s):

CGP 35348, GABA B Receptor Antagonist, CGP 35348, CGP35348, CGP-35348

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About This Item

Empirical Formula (Hill Notation):
C8H20NO4P
CAS Number:
123690-79-9
Molecular Weight:
225.22
UNSPSC Code:
12352200

Key Documents

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InChI key

QIIVUOWTHWIXFO-UHFFFAOYSA-N

InChI

1S/C8H20NO4P/c1-3-12-8(13-4-2)14(10,11)7-5-6-9/h8H,3-7,9H2,1-2H3,(H,10,11)

assay

≥98% (TLC)

form

solid

potency

34 μM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

water: 100 mM

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Primary Target
GABAB

Disclaimer

Toxicity: Standard Handling (A)

General description

A selective antagonist of post-synaptic GABAB receptors (IC50 = 34 µM) that can permeate the blood brain barrier. Exhibits about 10-fold lower affinity for pre-synaptic receptors. Blocks K+-evoked glycine exocytosis in mouse spinal cord and hippocampal nerve endings. Shown to antagonize the potentiating effect of L-baclofen on noradrenaline-induced stimulation of adenylate cyclase in rat cortex slices.

Other Notes

Romei, C., et al., 2010. Pharmacol. Res.61, 547.

Staubli, U., et al., 1999. J. Neurosci.19, 4609l.
Olpe, H.R., et al. 1990. Eur. J. Pharmacol.187, 27.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

wgk

WGK 3

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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