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5.06188

Sertraline Hydrochloride

Synonym(s):

Sertraline Hydrochloride, Serotonin (5-HT) Reuptake Inhibitor, Sertraline, Zoloft

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About This Item

Empirical Formula (Hill Notation):
C17H17Cl2N · xHCl
CAS Number:
79559-97-0
Molecular Weight:
306.23 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00895772
Assay:
≥99% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light
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assay

≥99% (HPLC)

Quality Level

100

form

solid

potency

3.3 nM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 100 mM, ethanol: 50 mM

storage temp.

2-8°C

SMILES string

[Cl-].Clc1c(ccc(c1)[C@@H]2CC[C@@H](c3c2cccc3)[N+H2]C)Cl

InChI

1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1

InChI key

BLFQGGGGFNSJKA-XHXSRVRCSA-N

General description

A very potent uptake inhibitor highly selective for serotonin (Ki = 3.3 nM). Clinically prescribed as an antidepressant drug. Often used in studying major depressive disorders.

Biochem/physiol Actions

Primary Target
5-HT uptake transporter

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Brunoni, R., et al. 2013. JAMA Psychiatry.70, 383.

Kobayashi, K., et al. 1995. Br. J. Clin. Pharmacol.40, 481.
Heym, J., et al. 1988. J. Clin. Psychiatry.49 Suppl, 40.
Koe, K., et al. 1983. J. Pharmacol. Exp. Ther.226, 700.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品

This item has

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Global Trade Item Number

SKUGTIN
506188000104055977243147