Sign Into View Organizational & Contract Pricing
About This Item
Empirical Formula (Hill Notation):
C33H33N3O15
CAS Number:
Molecular Weight:
711.63
UNSPSC Code:
12352200
PubChem Substance ID:
Assay
≥98% (HPLC)
Quality Level
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
ethanol: 25 mg/mL
storage temp.
2-8°C
SMILES string
CCOC(=O)C1=CC=C(C=C1)NC(=O)OC2C(OC(C(C2OC(=O)NC3=CC4=C(C=C3)OCO4)OC(=O)NC5=CC6=C(C=C5)OCO6)OC)CO
General description
A cell permeable, glucose-derived diversity oriented synthesized compound that acts as reversible inducer of PDX1 expression in human PANC-1 cells, primary human islets, and human duct derived cells in a dose-and time-dependent manner with maximal effect observed on day 9 at 5 µM. Its action is dependent on the presence of FOXA2 in cells as FOXA2 knockdown cells treated with this compound do not exhibit any effect on PDX1 expression. Shown to increase H3 acetylation and H3K4me3 and reduce H3K9me3, which is consistent with its transcriptional activation of PDX1. Prolonged treatment of PANC-1 cells (9 days) increases the expression of insulin mRNA and proteins levels. Does not affect cell number and does not influence apoptotic cell death in PANC-1 cells.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Biochem/physiol Actions
Cell permeable: yes
Reversible: yes
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Unstable in DMSO.
Other Notes
Yuan, Y., et al. 2013. Chem. Bio.20, 1513.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service