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About This Item
Empirical Formula (Hill Notation):
C11H8FNO2
CAS Number:
Molecular Weight:
205.19
MDL number:
UNSPSC Code:
12352200
Assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
orange
solubility
DMSO: 200 mg/mL
methanol: 5 mg/mL
storage temp.
−20°C
InChI
1S/C11H8FNO2S/c12-7-1-2-9-8(4-7)6(5-13-9)3-10(16)11(14)15/h1-5,13,16H,(H,14,15)/b10-3-
InChI key
HWMQHECFXSVZGN-KMKOMSMNSA-N
General description
A cell-permeable, non-peptidic, and highly selective calpain inhibitor directed towards the calcium binding sites of calpain. Displays over 20-fold greater selectivity for calpain-1 (Cat. Nos. 208712 and 208713) over calpain-2 (Cat. Nos. 208715 and 208718) (Ki values: 260 nM and 5.33 µM, respectively). Has been shown to prevent cycloheximide-induced apoptosis.
Biochem/physiol Actions
Primary Target
calpain-1
calpain-1
Target Ki: 260 nM against calpain-1
Preparation Note
Unstable in solution; reconstitute just prior to use.
Other Notes
Squier, M.K., et al. 1999. J. Cell Physiol.178, 311.
Wang, K.K., et al. 1996. Proc. Natl. Acad. Sci. USA93, 6687.
Wang, K.K., et al. 1996. Proc. Natl. Acad. Sci. USA93, 6687.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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