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516090-M

Millipore

Penciclovir

A carba analog of Ganciclovir. Active against several herpes viruses. Induces apoptosis effectively without exerting much genotoxicity.

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Synonym(s):
Penciclovir, 2-Amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6H-purin-6-one
Empirical Formula (Hill Notation):
C10H15N5O3
CAS Number:
39809-25-1
Molecular Weight:
253.26
MDL number:
MFCD15142866

Quality Level

100

Assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

water: 1 mg/mL
aqueous buffer, pH 2.0: 10 mg/mL

storage temp.

−20°C

InChI

1S/C10H15N5O3/c11-10-13-8-7(9(18)14-10)12-5-15(8)2-1-6(3-16)4-17/h5-6,16-17H,1-4H2,(H3,11,13,14,18)

InChI key

JNTOCHDNEULJHD-UHFFFAOYSA-N

General description

A carba analog of Ganciclovir (Cat. No. 345700). Active against several herpes viruses (IC50 = 37.9 µM for HHV-6A and 77.8 µM for HHV-6B). Induces apoptosis effectively without exerting much genotoxicity.
A synthetic acyclic guanine derivative and a carba analog of Ganciclovir (Cat. No. 345700) that is active against several herpes viruses (IC50 = 37.9 µM for HHV-6A and 77.8 µM for HHV-6B). Induces apoptosis effectively without exerting much genotoxicity.

Warning

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.

Other Notes

Leary, J.J., et al. 2002.Antimicrob. Agents Chemother.46, 762.
Amjad, M., et al. 2001. Microbiol. Immunol.45, 233.
Thust, R., et al. 2000. Cancer Gene Ther.7, 107.
Thust, R., et al. 1996. Antiviral Res.31, 105.
Shaw, T., et al. 1994. Antimicrob. Agents Chemother.38, 719.
Harnden, M.R. 1989. J. Med. Chem.32, 1738.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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