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About This Item
Empirical Formula (Hill Notation):
C15H10ClN3O
CAS Number:
Molecular Weight:
283.71
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
InChI key
FLYGLPYJEQPCFY-UHFFFAOYSA-N
InChI
1S/C15H10ClN3O/c16-10-6-4-9(5-7-10)13-8-18-12-3-1-2-11(15(17)20)14(12)19-13/h1-8H,(H2,17,20)
SMILES string
Clc1ccc(cc1)c2nc3c(nc2)cccc3C(=O)N
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
light brown
solubility
DMSO: 10 mg/mL
shipped in
ambient
Quality Level
Related Categories
General description
A potent quinoxaline-based PARP inhibitor with a ~5-fold selectivity towards PARP-2 over PARP-1 (IC50 = 7 and 33 nM, respectively). Reported to be brain-permeant and exhibit good pharmacokinetics.
Packaging
Packaged under inert gas
Other Notes
Ishida, J., et al. 2006. Bioorg. Med. Chem.14, 1378.
Iwashita, A., et al. 2005. FEBS Lett.579, 1389.
Iwashita, A., et al. 2005. FEBS Lett.579, 1389.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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