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Merck
CN

529605-M

PP1 Analog

InSolution, ≥97%, ATP-competitive, inhibitor of Src-family tyrosine kinases

Synonym(s):

InSolution PP1 Analog

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About This Item

Empirical Formula (Hill Notation):
C19H19N5
CAS Number:
221243-82-9
Molecular Weight:
317.39
UNSPSC Code:
12352200

Key Documents

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form

liquid

InChI key

XSHQBIXMLULFEV-UHFFFAOYSA-N

InChI

1S/C19H19N5/c1-19(2,3)24-18-15(17(20)21-11-22-18)16(23-24)14-10-6-8-12-7-4-5-9-13(12)14/h4-11H,1-3H3,(H2,20,21,22)

assay

≥97% (HPLC)

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

storage temp.

−70°C

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General description

A potent, reversible, ATP-competitive, and cell-permeable inhibitor of Src-family tyrosine kinases that is >800 times more selective for the I338G mutant v-Src (IC50 = 1.5 nM) compared to wild-type v-Src (IC50 = 1.0 µM). Also inhibits wild-type Fyn (IC50 = 600 nM). A 10 mM (1 mg/315 µl) solution of PP1 Analog (Cat. No. 529579) in DMSO.

Physical form

A 10 mM (1 mg/315 µl) solution of PP1 Analog (Cat. No. 529579) in DMSO.

Preparation Note

Following initial thaw, aliquot and freeze (-70°C).

Other Notes

Bishop, A.C., et al. 2000. Nature407, 395.
Bishop, A.C., et al. 1999 J. Am. Chem. Soc.121, 627.

Legal Information

Not available for sale in the United States.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - closed cup - (Dimethylsulfoxide)

flash_point_c

87 °C - closed cup - (Dimethylsulfoxide)

Certificates of Analysis (COA)

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