5.31206
Mnk2 Inhibitor IV
Synonym(s):
Mnk2 Inhibitor IV, Mitogen-activated protein kinase-interacting kinase 2
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About This Item
Empirical Formula (Hill Notation):
C17H18N4O3S
CAS Number:
Molecular Weight:
358.41
UNSPSC Code:
12352200
Assay
>98% (HPLC)
Quality Level
form
powder
potency
370 nM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
yellow
solubility
DMSO: 50 mg/mL
storage temp.
2-8°C
General description
A cell permeable phenylaminopyrimidine derived compound that acts as a selective inhibitor of mitogen-activated protein kinase-interacting kinase 2 (Mnk2, Ki = 370 nM. Displays high selectivity over CDK2 (Ki >10 µM) and CDK9 (Ki = 1.66 µM). Shown to block the phosphorylation of elF4E in and effectively inhibit the proliferation of MV4-11 cells (GI50 = 780 nM) by inducing a cell cycle arrest at G0/G1 phase. Diminishes the expression of Mcl-1 and causes PARP cleavage in A2780 ovarian cancer cells.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Mnk2
Mnk2
Reversible: yes
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Diab, S., et al. 2014. ChemMedChem.9, 962.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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