5.33065
Seriniquinone
Synonym(s):
Seriniquinone, Dinaphtho[2,3-b:2ʹ,3ʹ-d]thiophene-5,7,12,13-tetraone, Autophagy Inducer, Seriniquinone
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About This Item
Empirical Formula (Hill Notation):
C20H8O4S
CAS Number:
Molecular Weight:
344.34
UNSPSC Code:
12352200
Assay
≥98% (HPLC)
Quality Level
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
yellow
solubility
DMSO: 5 mg/mL
storage temp.
2-8°C
General description
A cell permeable dinaphthothiophenetetraone compound isolated from marine bacterium of the genus Serinicoccus that targets dermicidin and displays anti-cancer property against a wide range of cancer cell lines (mean GI = 758 nM, LC50 = 13.2 µM in NCI-60 panel). Exhibits highest potency against melanoma cell lines. Following its uptake it localizes rapidly into endoplasmic reticulum and induces autophagocytosis as evidenced by increased conversion of LC3A-I and LC3B-I to LC3A-II and LC3B-II, respectively. Also shown to induce apoptosis in HCT-116 cells with increase in caspase-3, 7, and 9 activation and cleavage of poly(ADP-ribose) polymerase.
Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
dermicidin
dermicidin
Reversible: yes
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Trzoss, L., et al. 2014. PNAS.111, 14687.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
新产品
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Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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