5.33087
Niclosamide Ethanolamine
Synonym(s):
Niclosamide Ethanolamine, NEN
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About This Item
Empirical Formula (Hill Notation):
C13H8Cl2N2O4 · C2H7NO
CAS Number:
Molecular Weight:
388.20
UNSPSC Code:
12352200
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 50 mg/mL
Quality Level
General description
A cell permeable, orally bioavailable, non-toxic salt form of niclosamide that acts as a reversible, mild uncoupler of mitochondria to reduce cellular energy efficiency and increase lipid oxidation. Also shown to reduce the mitochondrial membrane potential in live cells (~ 500 nM). Following oral uptake, it is distributed primarily in the liver. Improves glycemic control, improves insulin sensitivity,and reduces the level of glycated hemoglobin in C57BL/6J mice fed high fat diets. Retards the decline of plasma insulin level in db/db mice and improves their glycemic control. (150 mg/kg., p.o.). Activates AMPK and increases acetyl-CoA carboxylase phosphorylation, but does not affect the activity of gluconeogenic enzymes in the liver. Reported to reduce intracellular lipid accumulation in mice fed high fat diets.
Niclosamide Ethanolamine, NEN, AMPK activator
Biochem/physiol Actions
Cell permeable: yes
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Tao, H., et al. 2014. Nat. Med.20, 1263.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
signalword
Warning
hcodes
pcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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