5.33574
TRPML3 Activator, ML123
Synonym(s):
TRPML3 Activator, ML123, 4-Chloro-N-(2-morpholinocyclohexyl)benzenesulfonamide, SF-21, CID2911646, ML123, ML 123, Transient Receptor Potential Channel 3 Activator, SID24801657, Racemate, SR-1984
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C16H23ClN2O3S
CAS Number:
Molecular Weight:
358.88
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
Assay:
≥92% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
assay
≥92% (HPLC)
Quality Segment
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 50 mg/mL
storage temp.
2-8°C
SMILES string
C1CCC(C(C1)NS(=O)(=O)C2=CC=C(C=C2)Cl)N3CCOCC3
InChI key
AYQCZQKMGKDZPS-UHFFFAOYSA-N
General description
A non-cytotoxic morpholinyl-cyclohexylbenzenesulfonamide compound that acts as a selective agonist of TRPML3 channel (EC50 = 873 nM in hTRPML3-YPF transfected HEK293 cells). Displays significantly weaker agonistic activity for TRPML2 channel (54.5% at 10 µM) and is shown to be inactive against hTRPML1, hTRPM2, mTRPV2, hTRPC3, drTRPN1, and hTRPA1 (~10 µM). Also binds to sigma-1 receptor at much higher concentrations (IC50 = 31 µM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
TRPML3
TRPML3
Reversible: yes
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Antolin, A.A., and Mestres, J. 2015. ACS Chem. Biol.10, 395.
Grimm, C., et al. 2012. J. Biol. Chem.287, 22701.
Saldanha, S., et al. 2010. Probe Reports from the NIH Molecular Libraries Program.
Grimm, C., et al. 2010. Chem. Biol.17, 135.
Grimm, C., et al. 2012. J. Biol. Chem.287, 22701.
Saldanha, S., et al. 2010. Probe Reports from the NIH Molecular Libraries Program.
Grimm, C., et al. 2010. Chem. Biol.17, 135.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Signal Word
Warning
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Hazard Codes
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.