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Merck
CN

5.34034

Sigma-Aldrich

Heterochromatin Inhibitor, HMS-I1

Synonym(s):

Heterochromatin Inhibitor, HMS-I1, 2-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-6-methylimidazo[1,2-a]pyridine, 2-(2,3-Dihydro-1,4-benzo[b][1,4]dioxin-6-yl)-6-methylimidazo[1,2-a]pyridine, Heterochromatin Mediated Silencing Inhibitor 1

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About This Item

Empirical Formula (Hill Notation):
C16H14N2O2
CAS Number:
702636-92-8
Molecular Weight:
266.29
UNSPSC Code:
12352200
PubChem Substance ID:
2813456

Key Documents

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Assay

≥98% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

pale yellow

solubility

DMSO: 50 mg/mL

storage temp.

2-8°C

SMILES string

CC1=CN2C=C(N=C2C=C1)C3=CC4=C(C=C3)OCCO4

General description

A cell-permeable imidazopyridine based compound that lacks canonical zinc chelating moieties and acts in a reversible manner to disrupt heterochromatin-mediated transcriptional gene silencing in mammalian, fungal, and plant cells (5 - 10 µM). Targets Clr3-containing Snf2/HDAC repressor complex (SHREC) and inhibits HDAC6 and HDAC10 activities. Increases G418 resistance of cen1-kanMX cells. Shown to diminish H3K9 methylation and increase H3K9 and H3K14 acetylation in cells grown in the presence of G418. Murine erythroleukemia (MEL) cells grown in the presence of this compound can overcome α-satellite repeats-mediated gene silencing.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Clr3-containing Snf2/HDAC repressor complex (SHREC)
Reversible: yes

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Castonguay, E., et al. 2015. Mol. Cell. Biol.35, 662.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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