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Merck
CN

5.34329

H2S Fluorescent Probe, P3

Synonym(s):

H2S Fluorescent Probe, P3, ( E)-2-(3-(6-(2-Hydroxyethylamino)naphthalen-2-yl)-3-oxoprop-1-enyl)-3,5-dimethoxybenzaldehyde, Hydrogen Sulfide Fluorescent Probe, P3, Probe P3, (E)-2-(3-(6-(2-Hydroxyethylamino)naphthalen-2-yl)-3-oxoprop-1-enyl)-3,5-dimethoxybenzaldehyde, Hydrogen Sulfide Fluorescent Probe, P3, Probe P3

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About This Item

Empirical Formula (Hill Notation):
C24H23NO5
Molecular Weight:
405.44
NACRES:
NA.28
UNSPSC Code:
12352202

Key Documents

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assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

orange

solubility

DMSO: 100 mg/mL

fluorescence

λex 375 nm, λem 505 nm

Quality Level

100

Related Categories

General description

A cell-permeable, non-toxic, non-fluorescent naphthalenyl-dimethoxybenzaldehyde enone compound that acts as a highly specific, sensitive, fast-responsive H2S fluoroprobe (signal saturation at ≤ 5 min with a detection limit of 50 nM). Dose-dependently detects hydrogen sulfide levels under physiological conditions and readily fluoresces. Displays little to no reactivity towards GSH, Cys, H2O2, citrate and iodide (Hepes pH 7.4, containing 10% FBS). Also shown to be useful as a two-photon probe for imaging endogeneous H2S levels in HeLa cells. A thiol specific fluorescent probe is also available (Cat. No. 595504).Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
hydrogen sulfide
Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Singha, S., et al. 2015. Anal. Chem.87, 1188.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Regulatory Review (Z)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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