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Merck
CN

5.34329

H2S Fluorescent Probe, P3

Synonym(s):

H2S Fluorescent Probe, P3, ( E)-2-(3-(6-(2-Hydroxyethylamino)naphthalen-2-yl)-3-oxoprop-1-enyl)-3,5-dimethoxybenzaldehyde, Hydrogen Sulfide Fluorescent Probe, P3, Probe P3, (E)-2-(3-(6-(2-Hydroxyethylamino)naphthalen-2-yl)-3-oxoprop-1-enyl)-3,5-dimethoxybenzaldehyde, Hydrogen Sulfide Fluorescent Probe, P3, Probe P3

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About This Item

Empirical Formula (Hill Notation):
C24H23NO5
Molecular Weight:
405.44
NACRES:
NA.28
UNSPSC Code:
12352202

Key Documents

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assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

orange

solubility

DMSO: 100 mg/mL

fluorescence

λex 375 nm
λem 505 nm

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Cell permeable: yes
Primary Target
hydrogen sulfide
Reversible: no

Disclaimer

Toxicity: Regulatory Review (Z)

General description

A cell-permeable, non-toxic, non-fluorescent naphthalenyl-dimethoxybenzaldehyde enone compound that acts as a highly specific, sensitive, fast-responsive H2S fluoroprobe (signal saturation at ≤ 5 min with a detection limit of 50 nM). Dose-dependently detects hydrogen sulfide levels under physiological conditions and readily fluoresces. Displays little to no reactivity towards GSH, Cys, H2O2, citrate and iodide (Hepes pH 7.4, containing 10% FBS). Also shown to be useful as a two-photon probe for imaging endogeneous H2S levels in HeLa cells. A thiol specific fluorescent probe is also available (Cat. No. 595504).Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Other Notes

Singha, S., et al. 2015. Anal. Chem.87, 1188.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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